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KMID : 0616120070380040394
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 4 p.394 ~ p.399
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Isolation of Melanin Biosynthesis Inhibitory Compounds from the Roots of Asarum sieboldii
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Choi Een-Hyang
Choi Ji-Young
Lee Jong-Koo
Oh Joon-Seok
Kim Dong-Chun
Lee Hee-Sang
Son Jong-Keun
Son Ae-Ryang
Kim Jeong-Ah
Lee Seung-Ho
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Abstract
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Eight compounds were isolated from the roots of Asarum sieboldii and their structures were identified as (±)-car-3-ene-2,5-dione (1), (-)-asarinin (2), (-)-sesamin (3), eucarvone (4), methyleugenol (5), γ-asarone (6), pellitorine (7) and asarinol A (8) by analysis of spectral data. Among them, (-)-asarinin (2) showed the most potent inhibitory effect on melanogenesis, with inhibition rate of 66%.
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KEYWORD
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Asarum sieboldii, melanogenesis inhibitor, (-)-asarinin, methyleugenol
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